Reactive species
Human,Mouse,Rat
Protein name
Multidrug resistance protein 1
Immunogen
The antiserum was produced against synthesized peptide derived from human P-glycoprotein 1. AA range:534-583
Specificity
The antiserum was produced against synthesized peptide derived from human P-glycoprotein 1. AA range:534-583
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal,Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Other name
p-pg ;
ABCB1 ;
MDR1 ;
PGY1 ;
Multidrug resistance protein 1 ;
ATP-binding cassette sub-family B member 1 ;
P-glycoprotein 1 ;
CD antigen CD243
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Function
Catalytic activity:ATP + H(2)O + xenob
