Background
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced
production of this protein has been observed in patients with chronic renal failure (CRF), and
this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis,
osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been
associated with ageing and bone loss.
