Background
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which
modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent
on DNA and is involved in the regulation of various important cellular processes such as
differentiation, proliferation, and tumor transformation and also in the regulation of the
molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme
may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology
of type I diabetes.
