Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 371-470 of human
FMO1
Source
Monoclonal,Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
FMO1; flavin containing monooxygenase 1
Background
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavincontaining monooxygenase and is subject to an inherited FMO3 polymorphism in man
resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish
odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver,
FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region.
Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the
oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
Several transcript variants encoding different isoforms have been found for this gene.
