Reactive species
Human,Mouse,Rat
Protein name
Myeloperoxidase
Immunogen
Synthesized peptide derived from human Myeloperoxidase(MPO) AA range: 350-450
Specificity
This antibody detects endogenous levels of MPO protein.
Constitute
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Monoclonal,Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
This antibody detects endogenous levels of MPO protein.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Other name
84 kDa myeloperoxidase antibody ;
89 kDa myeloperoxidase antibody ;
EC1.11.2.2 antibody ;
fj80f04 antibody ;
MPO antibody ;
mpx antibody ;
myeloid-specific peroxidase antibody ;
Myeloperoxidase antibody ;
Myeloperoxidase heavy chain antibody ;
Myeloperoxidase light chain antibody ;
PERM_HUMAN antibody ;
wu:fj80f04 antibody
Background
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Function
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage
