Reactive species
Human,Mouse,Rat
Immunogen
A phospho specific peptide corresponding to residues surrounding Y1173 of human EGFR
Source
Monoclonal,Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
ERBB; ERRP; HER1; mENA; ERBB1; PIG61; NISBD2; Phospho-EGFR-Y1173
Background
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the
protein kinase superfamily. This protein is a receptor for members of the epidermal growth
factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus
inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation.
Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine
storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting
from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
