Background
This gene belongs to the reticulon family of highly conserved genes that are preferentially
expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the
activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta.
An increase in the expression of any reticulon protein substantially reduces the production of
amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells.
Alternatively spliced transcript variants encoding different isoforms have been found for this
gene, and pseudogenes of this gene are located on chromosomes 4 and 12
