Reactive species
Human; Mouse;Rat
Immunogen
Recombinantfusionproteincontainingasequencecorrespondingtoaminoacids 466-665ofhumanKCNQ2(NP_742105.1).
Constitute
PBSwith0.01%thimerosal,50%glycerol,pH7.3.
Source
Monoclonal,Mouse,IgG
Dilution rate
WB1:500-1:1000
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Background
The M channel is a slowly activating and deactivating potassium channel that plays a critical
role in the regulation of neuronal excitability. The M channel is formed by the association of
the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both
integral membrane proteins. M channel currents are inhibited by M1 muscarinic
acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in
this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as
epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five
different isoforms have been found for this gene
