Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of
human Bcl-XL
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
BCLX; BCL2L; Bcl-X; PPP1R52; BCL-XL/S; Bcl-XL
Background
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family
members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are
involved in a wide variety of cellular activities. The proteins encoded by this gene are
located at the outer mitochondrial membrane, and have been shown to regulate outer
mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane
potential, and thus controls the production of reactive oxygen species and release of
cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.
Alternative splicing results in multiple transcript variants encoding two different isoforms.
The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an
apoptotic activator.
