Reactive species
Human,Mouse,Rat
Immunogen
A synthetic phosphorylated peptide around T14 of human CDK1(NP_001777.1).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
CDC2; CDC28A; P34CDC2; Phospho-CDK1-T14
Background
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This
protein is a catalytic subunit of the highly conserved protein kinase complex known as Mphase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of
eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as
regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation
and destruction through the cell cycle. The phosphorylation and dephosphorylation of this
protein also play important regulatory roles in cell cycle control. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene.
