Background
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted
protein with a C-terminal cystine knot-like domain. This protein functions as a bone
morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs,
prohibiting them from binding their receptors, thereby regulating BMP signaling during
cellular proliferation, differentiation, and programmed cell death.
