Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-122 of
human RPL22 (NP_000974.1)
Dilution rate
WB 1:1000- 1:5000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
EAP; L22; HBP15; HBP15/L22; 22
Background
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and
a large 60S subunit. Together these subunits are composed of 4 RNA species and
approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal
protein that is a component of the 60S subunit. The protein belongs to the L22E family of
ribosomal proteins. Its initiating methionine residue is post-translationally removed. The
protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse
protein has been shown to be capable of binding to heparin. Transcript variants utilizing
alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are
multiple processed pseudogenes of this gene dispersed through the genome. It was
previously thought that this gene mapped to 3q26 and that it was fused to the acute
myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic
syndrome patients with 3;21 translocations; however, these fusions actually involve a
ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-
p36.2
