Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-201 of human
TAGLN (NP_003177.2
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
SM22; SMCC; TAGLN1; WS3-10; SM22-alpha
Background
This gene encodes a shape change and transformation sensitive actin-binding protein which
belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth
muscle, and is an early marker of smooth muscle differentiation. The encoded protein is
thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor
suppressor, and the loss of its expression is an early event in cell transformation and the
development of some tumors, coinciding with cellular plasticity. The encoded protein has a
domain architecture consisting of an N-terminal calponin homology (CH) domain and a Cterminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are
viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution
of the actin filament and changes in cytoskeletal organization.
