Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 368-467 of human IRF6
(O14896)
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1; IRF6
Background
This gene encodes a member of the interferon regulatory transcription factor (IRF) family.
Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain
and a less conserved C-terminal protein-binding domain. The encoded protein may be a
transcriptional activator. Mutations in this gene can cause van der Woude syndrome and
popliteal pterygium syndrome. Mutations in this gene are also associated with nonsyndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants
