Background
This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a
component of the blood clot. Following vascular injury, the encoded preproprotein is
proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations
in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia,
afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript
variants, at least one of which encodes an isoform that undergoes proteolytic processing
