Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human
Complement factor H (P08603).
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Other name
FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; Complement factor H
Background
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and
encodes a protein with twenty short consensus repeat (SCR) domains. This protein is
secreted into the bloodstream and has an essential role in the regulation of complement
activation, restricting this innate defense mechanism to microbial infections. Mutations in
this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic
hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized.
