Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required
for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of
unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle
proteins involved in DNA damage responses, that also associate with chromatin in meiotic
prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for
cells to delay cell cycle progression in response to double-strand DNA breaks. Several
alternatively spliced transcript variants have been found for this gene.
