Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Background
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and
a large 60S subunit. Together these subunits are composed of 4 RNA species and
approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal
protein that is a component of the 40S subunit. The protein belongs to the S6E family of
ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets
of five C-terminal serine residues phosphorylated by different protein kinases.
Phosphorylation is induced by a wide range of stimuli, including growth factors, tumorpromoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein
may contribute to the control of cell growth and proliferation through the selective
translation of particular classes of mRNA. As is typical for genes encoding ribosomal
proteins, there are multiple processed pseudogenes of this gene dispersed through the
genome.
