Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of
human TRAF3IP2 (NP_671733.2).
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Other name
ACT1; CIKS; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; PSORS13; TRAF3IP2
Background
This gene encodes a protein involved in regulating responses to cytokines by members of
the Rel/NF-kappaB transcription factor family. These factors play a central role in innate
immunity in response to pathogens, inflammatory signals and stress. This gene product
interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either IkappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative
transcripts encoding different isoforms have been identified. Another transcript, which does
not encode a protein and is transcribed in the opposite orientation, has been identified.
Overexpression of this transcript has been shown to reduce expression of at least one of the
protein encoding transcripts, suggesting it has a regulatory role in the expression of this
gene.
