Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of
human Cardiac Troponin I (TNNI3) (NP_000354.4).
Dilution rate
0.73611111111111
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Other name
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; Cardiac Troponin I (TNNI3)
Background
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that
form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory
subunit; blocking actin-myosin interactions and thereby mediating striated muscle
relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletalslow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively
expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic
cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is
useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated
level of troponin is also now used as indicator of acute myocardial injury in patients
hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has
also been associated with higher risk of mortality in cardiovascular disease patients
hospitalized due to COVID-19.
