Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1824-2003
of human NOTCH4 (NP_004548.3
Dilution rate
WB 1:100 - 1:500
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Background
This gene encodes a member of the NOTCH family of proteins. Members of this Type I
transmembrane protein family share structural characteristics including an extracellular
domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an
intracellular domain consisting of multiple different domain types. Notch signaling is an
evolutionarily conserved intercellular signaling pathway that regulates interactions between
physically adjacent cells through binding of Notch family receptors to their cognate ligands.
The encoded preproprotein is proteolytically processed in the trans-Golgi network to
generate two polypeptide chains that heterodimerize to form the mature cell-surface
receptor. This receptor may play a role in vascular, renal and hepatic development.
Mutations in this gene may be associated with schizophrenia. Alternative splicing results in
multiple transcript variants, at least one of which encodes an isoform that is proteolytically
processed.
