Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 2200-2321 of human
NOTCH3 (NP_000426.2)
Dilution rate
WB 1:1000- 1:5000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Other name
IMF2; LMNS; CASIL; CADASIL; CADASIL1; NOTCH3
Background
This gene encodes the third discovered human homologue of the Drosophilia melanogaster
type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands
(delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural
development. Homologues of the notch-ligands have also been identified in human, but
precise interactions between these ligands and the human notch homologues remains to be
determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral
autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
(CADASIL).
