Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Background
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane
protein family share structural characteristics including an extracellular domain consisting of
multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting
of multiple, different domain types. Notch family members play a role in a variety of
developmental processes by controlling cell fate decisions. The Notch signaling network is
an evolutionarily conserved intercellular signaling pathway which regulates interactions
between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound
ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in
development. Homologues of the notch-ligands have also been identified in human, but
precise interactions between these ligands and the human notch homologues remain to be
determined. This protein is cleaved in the trans-Golgi network, and presented on the cell
surface as a heterodimer. This protein functions as a receptor for membrane bound ligands,
and may play a role in vascular, renal and hepatic development. Two transcript variants
encoding different isoforms have been found for this gene
