Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 2456-2555 of human
Notch1 (P46531).
Dilution rate
WB 1:500 - 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Other name
hN1; AOS5; TAN1; AOVD1; Notch1
Background
This gene encodes a member of the NOTCH family of proteins. Members of this Type I
transmembrane protein family share structural characteristics including an extracellular
domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an
intracellular domain consisting of multiple different domain types. Notch signaling is an
evolutionarily conserved intercellular signaling pathway that regulates interactions between
physically adjacent cells through binding of Notch family receptors to their cognate ligands.
The encoded preproprotein is proteolytically processed in the trans-Golgi network to
generate two polypeptide chains that heterodimerize to form the mature cell-surface
receptor. This receptor plays a role in the development of numerous cell and tissue types.
Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, Tcell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck
squamous cell carcinoma.
