Reactive species
Human,Mouse,Rat
Immunogen
Recombinant Protein corresponding to a sequence within amino acids 16-230 of human
DSPP(NP_055023.2).
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
DPP; DSP; DGI1; DMP3; DFNA39; DSPP
Background
This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein
(SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and
proteolytically processed to generate two principal proteins of the dentin extracellular matrix
of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may
play distinct but related roles in dentin mineralization. Mutations in this gene are associated
with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster
on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this
gene.
