Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1571-1870 of human CCDC88A (NP_001129069.1).
Dilution rate
WB 1:500 - 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
APE; GIV; GRDN; PEHO; HkRP1; PEHOL; GIRDIN; KIAA1212; CCDC88A
Background
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins.
The encoded protein is an actin-binding protein that is activated by the serine/threonine
kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded
protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-
dependent activation of Akt by growth factor receptor tyrosine kinases and G proteincoupled receptors. Increased expression of this gene and phosphorylation of the encoded
protein may play a role in cancer metastasis. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene.
