Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 697-796 of human TLR6
(NP_006059.2).
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which
plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs
are highly conserved from Drosophila to humans and share structural and functional
similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are
expressed on infectious agents, and mediate the production of cytokines necessary for the
development of effective immunity. The various TLRs exhibit different patterns of
expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular
response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of
the encoded protein may be associated with an increased of asthma is some populations.
