Background
The protein encoded by this gene is a preprohormone which is cleaved to form two
biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide.
Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation
of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The
antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S.
aureus at low concentration.
