Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 107-206 of human
SNAP25 (P60880).
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
SUP; RIC4; SEC9; SNAP; CMS18; RIC-4; SNAP-25; bA416N4.2; dJ1068F16.2; SNAP25
Background
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble Nethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle
membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/tSNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and
the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin
supplies one helix and the protein encoded by this gene contributes the other two.
Therefore, this gene product is a presynaptic plasma membrane protein involved in the
regulation of neurotransmitter release. Two alternative transcript variants encoding different
protein isoforms have been described for this gene.
