Reactive species
Human,Rat
Protein name
Ancient ubiquitous protein 1
Immunogen
Synthesized peptide derived from human AUP1
Specificity
This antibody detects endogenous levels of AUP1 at Human,Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome . Plays a role in lipid droplet formation . Induces lipid droplet clustering . Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation . Also required for the degradation of INSIG1, SREBF1 and SREBF2 . Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB . ; (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.
