Reactive species
Human,Mouse,Rat
Immunogen
Recombinant protein fo a sequence within amino acids 50-150 of human LEF1 (Q9UJU2).
Dilution rate
WB 1:500 - 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
LEF-1; TCF10; TCF7L3; TCF1ALPHA; LEF1
Background
This gene encodes a transcription factor belonging to a family of proteins that share
homology with the high mobility group protein-1. The protein encoded by this gene can bind
to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring
maximal enhancer activity. This transcription factor is involved in the Wnt signaling
pathway, and it may function in hair cell differentiation and follicle morphogenesis.
Mutations in this gene have been found in somatic sebaceous tumors. This gene has also
been linked to other cancers, including androgen-independent prostate cancer. Alternative
splicing results in multiple transcript variants.
