Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MSH2
(P43246).
Dilution rate
WB 1:500 - 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
FCC1; COCA1; HNPCC; LCFS2; MSH-2; hMSH2; HNPCC1; LYNCH1; MMRCS2; MSH2
Background
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When
cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS,
consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype)
found in HNPCC. Two transcript variants encoding different isoforms have been found for this
gene.
