Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 70-145 of human LATS2
(NP_055387.2).
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Background
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor
family. The protein localizes to centrosomes during interphase, and early and late
metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for
accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also
interacts with a negative regulator of p53 and may function in a positive feedback loop with
p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of
androgen-responsive gene expression.
