Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of
human BMPR1B (NP_001194.1).
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
ALK6; AMD3; AMDD; BDA2; ALK-6; BDA1D; CDw293; BMPR1B
Background
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of
transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are
members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation
and embryogenesis. These proteins transduce their signals through the formation of
heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I
receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind
ligands in the absence of type I receptors, but they require their respective type I receptors
for signaling, whereas type I receptors require their respective type II receptors for ligand
binding. Mutations in this gene have been associated with primary pulmonary hypertension.
Several transcript variants encoding two different isoforms have been found for this gene.
