Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 849-1041
of human TLR8 (NP_619542.1).
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
CD288; IMD98; hTLR8; TLR8
Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which
plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs
are highly conserved from Drosophila to humans and share structural and functional
similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are
expressed on infectious agents, and mediate the production of cytokines necessary for the
development of effective immunity. The various TLRs exhibit different patterns of
expression. This gene is predominantly expressed in lung and peripheral blood leukocytes,
and lies in close proximity to another family member, TLR7, on chromosome X.
