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LXR beta/NER Mouse mAb

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Product code: YP-mAb-18358
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Product introduction

Reactive species
Human,Mouse,Rat
Applications
WB
Antibody type
单克隆抗体
Gene Name
Protein name
Dalton（DA）
51kDa
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human LXR beta/NER. (P55055).
Specificity
Constitute
Source
Dilution rate
WB 1:100 - 1:500
Purification process
Affinity purification
Concentration
1 mg/ml
Stockpile
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
NER; UNR; LXRB; LXR-b; NER-I; RIP15; LXR beta/NER
Background
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).
Function

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