Reactive species
Human,Mouse,Rat
Immunogen
A synthetic phosphorylated peptide around S441 of mouse MLKL (NP_001297542.1)
Dilution rate
WB 1:500 - 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
9130019I15Rik; Phospho-MLKL-S441
Background
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein
kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a
critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death
process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling
molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential
for necroptosis. Alternatively spliced transcript variants have been found for this gene
