Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of
human APRT (NP_000476.1)
Dilution rate
WB 1:500 - 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
AMP; APRTD; APRT
Background
Adenine phosphoribosyltransferase belongs to the purine/pyrimidine
phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG
dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate
from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a
by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme
causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms
have been found for this gene
