Reactive species
Human,Mouse,Rat
Immunogen
A synthetic phosphorylated peptide around T387 of human MST1/STK4 (NP_006273.1).
Dilution rate
WB 1:500 - 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
KRS2; MST1; YSK3; Phospho-MST1/STK4-T387
Background
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the
yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein
kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes
autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to
be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this
protein has been correlated with apoptosis, and it's possible that this protein induces the
chromatin condensation observed in this process.
