Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 16-215 of
human HAND1 (NP_004812.1).
Dilution rate
WB 1:500 - 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
Hxt; eHand; Thing1; bHLHa27; HAND1
Background
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription
factors. This gene product is one of two closely related family members, the HAND proteins,
which are asymmetrically expressed in the developing ventricular chambers and play an
essential role in cardiac morphogenesis. Working in a complementary fashion, they function
in the formation of the right ventricle and aortic arch arteries, implicating them as mediators
of congenital heart disease. In addition, it has been suggested that this transcription factor
may be required for early trophoblast differentiation.
