Reactive species
Human;Mouse;Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 22-557 of
mouse CD62E(NP_035475.2).
Dilution rate
WB 1:500 - 1:1000
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Other name
Elam; CD62E; ELAM-1; LECAM2; E-selectin
Function
Predicted to enable several functions, including oligosaccharide binding activity;
phospholipase binding activity; and sialic acid binding activity. Involved in positive regulation
of leukocyte tethering or rolling. Acts upstream of or within positive regulation of leukocyte
migration. Predicted to be located in several cellular components, including caveola;
clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be integral component
of plasma membrane. Predicted to be active in external side of plasma membrane and
extracellular space. Is expressed in several structures, including adrenal gland; genitourinary
system; incisor; integumental system; and limb segment. Human ortholog(s) of this gene
implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary
artery disease. Orthologous to human SELE (selectin E).
