Reactive species
Human,Mouse,Rat
Dalton（DA）
Calculated MW: 71 kDa; Observed MW: 55 kDa
Immunogen
A synthesized peptide derived from human TXNRD1
Dilution rate
WB: 1/500-1/1000
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles
Other name
TR; TR1; TXNR; TRXR1; GRIM-12
Background
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
