Reactive species
Human;Rat;Mouse;
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 204-463 of
human DLC1 (NP_079043.3).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
HP; ARHGAP7; STARD12; p122-RhoGAP; DLC1
Background
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family
of proteins which play a role in the regulation of small GTP-binding proteins. GAP family
proteins participate in signaling pathways that regulate cell processes involved in
cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of
common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript
variants due to alternative promoters and alternative splicing have been found for this gene.
