Background
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from
CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of
GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal
transduction, and cell transformation. Several alternatively spliced transcript variants of this
gene have been described, but the full-length nature of some variants has not been
determined.
