Reactive species
Human;Mouse;Rat
Protein name
Chromogranin-A
Immunogen
The antiserum was produced against synthesized peptide derived from human Chr-A. AA range:311-360
Specificity
Chr-A Monoclonal Antibody detects endogenous levels of Chr-A protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB: 1/500 - 1/2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
CHGA; Chromogranin-A; CgA; Pituitary secretory protein I; SP-I
Background
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],
Function
function:Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.,miscellaneous:Binds calcium with a low-affinity.,PTM:Sulfated on tyrosine residues and/or contains sulfated glycans.,similarity:Belongs to the chromogranin/secretogranin protein family.,subcellular location:Neuroendocrine and endocrine secretory granules.,
