Reactive species
Human;Mouse;Rat
Protein name
Protein delta homolog 1
Immunogen
Purified recombinant fragment of human DLK1 expressed in E. Coli.
Specificity
DLK1 Monoclonal Antibody detects endogenous levels of DLK1 protein.
Constitute
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification process
Affinity purification
Other name
DLK1; DLK; Protein delta homolog 1; DLK-1; pG2
Background
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015],
Function
alternative products:Additional isoforms seem to exist,function:May have a role in neuroendocrine differentiation.,PTM:N- and O-glycosylated.,similarity:Contains 6 EGF-like domains.,subunit:Monomer.,tissue specificity:Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue.,
