Reactive species
Human;Mouse;Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 920-1140
of human GRM1 (NP_001264993.1).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85; GRM1
Background
This gene encodes a metabotropic glutamate receptor that functions by activating
phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous
system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic
neurotransmission is involved in most aspects of normal brain function and can be perturbed
in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a
disulfide-linked homodimer whose activity is mediated by a G-protein-coupled
phosphatidylinositol-calcium second messenger system. This gene may be associated with
many disease states, including schizophrenia, bipolar disorder, depression, and breast
cancer. Alternative splicing results in multiple transcript variants encoding different
isoforms.
