Reactive species
Human;Mouse;Rat
Protein name
Beta-3 adrenergic receptor
Immunogen
The antiserum was produced against synthesized peptide derived from human ADRB3. AA range:250-299
Specificity
AR-β3 Monoclonal Antibody detects endogenous levels of AR-β3 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
ADRB3; ADRB3R; B3AR; Beta-3 adrenergic receptor; Beta-3 adrenoreceptor; Beta-3 adrenoceptor
Background
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009],
Function
function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.,polymorphism:The variant Arg-64 seems to be associated with weight gain (obesity) and to is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed mainly in adipose tissues.,
