Reactive species
Human;Mouse;Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HTR2A
(NP_000612.1)
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Other name
HTR2; 5-HT2A; HTR2A
Background
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles.
Mutations in this gene are associated with susceptibility to schizophrenia and obsessivecompulsive disorder, and are also associated with response to the antidepressant citalopram
in patients with major depressive disorder (MDD). MDD patients who also have a mutation in
intron 2 of this gene show a significantly reduced response to citalopram as this
antidepressant downregulates expression of this gene. Multiple transcript variants encoding
different isoforms have been found for this gene
