Reactive species
Human;Rat;Mouse;
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-85 of
human NBR1 (NP_005890.2).
Dilution rate
WB: 1:1000-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
IAI3B; M17S2; MIG19; 1A1-3B; NBR1
Background
The protein encoded by this gene was originally identified as an ovarian tumor antigen
monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is
present in many genes with transformation potential. It functions as a specific autophagy
receptor for the selective autophagic degradation of peroxisomes by forming intracellular
inclusions with ubiquitylated autophagic substrates. This gene is located on a region of
chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene.
Alternative splicing of this gene results in multiple transcript variants.
